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Eun-Seok Park / Sun Dong Yoo / Kang Ro Lee / Kang Choon Lee / Byung-Mu Lee / Seok-Yong Lee / Sun-Mee Lee / Choon-Gon Jang / Kyu-Hyuck Chung / Young-Hoon Jung / Dong-Gyu Jo / Eun-Jung Cho / OkPyo Zee / Suhkneung Pyo / Jeung Whan Han / Won-Hun Ham /
 

Name Young Hee Lee
Position Division Professor
E-mail espark@skku.ac.kr
Office Tel 031)290-7715
Education 1977-1981 B.Sc., Sungkyunkwan University (Pharmacy)
1986-1989 M.Sc., University of Iowa (Pharmacokinetics)
1989-1994 Ph.D., Medical University of South Carolina (Physical Pharmacy)
Work Experience 1995-1996 Research Institute for Pharmaceutical Sciences and Research Scientist, Basic Science Research Center, Sungkyunkwan University (Research Scientist)
1996-2000 College of Pharmacy, Sungkyunkwan University (Assistant Professor)
2000-2006 College of Pharmacy, Sungkyunkwan University (Associate Professor)
2004-2006 Pharmaceutical Society of Korea (Associate Editor of Archives of Pharmacal Research)
2006-Present College of Pharmacy, Sungkyunkwan University (Professor)
2006-present Phamaceutical Society of Korea (Editor of APR)
Research Interests Preformulation
Development of polymeric drug delivery systems
Formulation of nano-and micro-particulates
Formulation of macro- & microemulsions
Stability study
Selected Publications Rhee YS, Park CW, Kim KJ, Chi SC, Park ES., Behavior of itraconazole and benzyl alcohol in aqueous solution containing nonionic surfactants. Arch Pharm Res. 30(2):240-8. (2007)
Rhee YS, Park CW, Nam TY, Shin YS, Chi SC, Park ES., Formulation of parenteral microemulsion containing itraconazole, Arch Pharm Res. 30(1):114-23 (2007)
D.C.Son, N.Thuong, E.-S. Park and S.-C. Chi. High Performance Liquid Chromatographic Analysis of Rebamipide in Human Plasma. Analytical Letters. 38:997-1005 (2005)
Kim SC, Yoon HJ, Lee JW, Yu JW, Park ES, Chi SC. Investigation of the release behavior of DEHP from infusion sets by paclitaxel-loaded polymeric micelles. International Journal of Pharmaceutics. 293:303-310 (2005)
Kim SC, Yu J, Lee JW, Park ES, Chi SC. Sensitive HPLC method for quantitation of paclitaxel(Genexol) in biological samples with application to preclinical pharmacokinetics and biodistribution. Journal of Pharmaceutical and Biomedical Analysis. 39(12):170-176 (2005)

Name Sun Dong Yoo
Position Division Professor
E-mail sdyoo@skku.ac.kr
Office Tel 031)290-7717,7757
Education 1972-74,78-80 B.Sc.Sungkyunkwan University (Pharmacy)
1982-1984 University of Manitoba, Canada (Biopharmaceutics)
1985-1989 University of British Columbia, Canada (Pharmacokinetics)
Work Experience 1984-1989 Teaching and Research Assistant, University of British Columbia (Canada)
1989-1991 Post-doctoral Fellow, College of Pharmacy, University of Kentucky (USA)
1991-1997 Assistant Professor, College of Pharmacy, University of South Carolina (USA)
1997-2002 Associate Professor, College of Pharmacy, Sungkyunkwan University
2002-2004 Chairman, College of Pharmacy, Sungkyunkwan University
2004-2006 Dean, College of Pharmacy, Sungkyunkwan University
2004-2006 Director, Research Institute of Pharmaceutical Sciences, Sungkyunkwan University
2004-2006 Dean, Graduate School of Clinical Pharmacy, Sungkyunkwan University
2002-present Professor, College of Pharmacy, Sungkyunkwan University
Research Interests Preclinical and Clinical ADME
Biopharmaceitucs
Protein and Peptide Kinetics
PB/PK and PK/PD Modeling
Selected Publications Shin BS, Choi JW, Balthasar JP, Hong DK, Kim JJ, Yoo SD. Determination of roxatidine in human plasma by liquid chromatography/electrospray mass spectrometry and application to a clinical pharmacokinetic study. Rapid Communications in Mass Spectrometry. 21(3):329-335 (2007)
Yoon CH, Kim SJ, Shin BS, Lee KC, Yoo SD. Rapid Screening of Blood-Brain Barrier Penetration of Drugs Using the Immobilized Artificial Membrane Phosphatidylcholine Column Chromatography. Journal of Biomolecular Screening. 11(1):13-20 (2006)
Shin BS, Chang HS, Park EH, Yoon CH, Kim HY, Kim J, Ryu JK, Zee OP, Lee KC, Cao D, Yoo SD. Pharmacokinetics of a Novel Histone Deacetylase Inhibitor, Apicidin, in Rats. Biopharmaceutics & Drug Disposition. 27(2):69-75 (2006)
Shin BS, Kim CH, Jun YS, Park EH, Hur MW, Lee KC, Yoon YS, Lee MN, Yoo SD. Dose-linear pharmacokinetics, tissue distribution, and excretion of a recombinant fusion protein 125I-GST-TatdMt possessing potent anti-obesity activity. Regulatory Peptides. 129(1-3):25-30 (2005)
Shin BS, Park EH, Yoon CH, Kim J, Zee O, Yoo SD. In vitro investigation of the hepatic intrinsic clearance of apicidin, a histone deacetylase inhibitor, in mouse, rat, and human, with correction by nonspecific protein binding. Journal of Toxicology and Environmental Health A. 68(23-24):2207-2218 (2005)

Name Kang Ro Lee
Position Division Professor
E-mail krlee@skku.ac.kr
Office Tel 031)290-7710, 7750
Education 1980 B.Sc., Sungkyunkwan University (Pharmacy)
1982 M.Sc., Seoul National University (Pharmacognosy)
1989 Ph.D., Bonn University, Germany (Natural Products Chemistry)
Work Experience 1983-1985 Daewoong Research Institute
1989-1990 Korea Institute of Science and Technology (KIST)
1991-1995 College of Pharmacy, Sungkyunkwan University (Assistant Professor)
1995-2000 College of Pharmacy, Sungkyunkwan University (Associate Professor)
2000-Present College of Pharmacy, Sungkyunkwan University (Professor)
Research Interests Isolation and structural determination of bioactive natural products
Terpenoids of Compositae
Cytotoxic constituents of natural products
Peroxide constituents from natural sources
Selected Publications Min YD, Kwon HC, Yang MC, Lee KH, Choi SU, Lee KR. Isolation of Limonoids and Alkaloids from Phellodendron amurense and Their Multidrug Resistance (MDR) Reversal Activity. Archives of Pharmacal Research. 30(1):58-63 (2007)
Park KM, Yang MC, Lee KH, Kim KR, Choi SU, Lee KR. Cytotoxic Phenolic Constituents of Acer tegmentosum Maxim. Archives of Pharmacal Research. 29(12):1086-1090 (2006)
Min YD, Yang MC, Lee KH, Kim KR, Choi SU, Lee KR. Protoberberine Alkaloids and their Reversal Activity of P-gp Expressed Multidrug Resistance (MDR) from the Rhizome of Coptis japonica Makino. Archives of Pharmacal Research. 29(9):757-761 (2006)
Min YD, Choi SU, Lee KR. Aporphine Alkaloids and their Reversal Activity of Multidrug Resistance (MDR) from the Stems and Rhizomes of Sinomenium acutum. Archives of Pharmacal Research. 29(8):627-632 (2006)
Lee SO, Choi SZ, Choi SU, Lee KC, Chin YW, Kim J, Kim YC, Lee KR. Labdane diterpenes from Aster spathulifolius and their cytotoxic effects on human cancer cell lines. J Nat Prod. 68(10):1471-4 (2005))

Name Kang Choon Lee
Position Division Professor
E-mail kclee@skku.ac.kr
Office Tel 031)290-7704, 7744
Education 1967-1971 B.Sc., College of Pharmacy, SungKyunKwan University (Pharmacy)
1971-1973 M.Sc., College of Pharmacy, Sungkyunkwan University (Analytical Pharmacy)
1978-1981 Ph.D., College of Pharmacy, Sungkyunkwan University (Analytical Pharmacy)
Work Experience 1982-1991 College of Pharmacy, Chonnam National University (Associate Professor)
1989-1990 College of Pharmacy, University of Kentucky (Visiting Professor)
1996-1998 College of Pharmacy, Sungkyunkwan University (Dean)
1992-present College of Pharmacy, Sungkyunkwan University (Professor)
1999-2000 Vice president, Pharmaceutical Society of Korea
2000-2003 Vice president, Korean Society of Pharmaceutics
2002-2003 President, Korean-American Pharmaceutical Scientists Association
2001-present Editorial Advisory Board member, Pharmaceutical Research (AAPS journal, Plenum, SCI)
2002-present Editorial Advisory Board member, PharmSciTech (AAPS e-journal, SCIE)
Research Interests Sample preparation for the trace enrichment of organic compounds of interest from complex sample matrices
Analysis and identification of organic compounds by GC, CE and GC-MS
Profiling and screening analysis for the clinical monitoring and pattern recognition
Enantiomeric separation of chiral compounds by GC and CE.
Method development of pattern recognition on the organic metabolic profiles
Selected Publications Youn YS, Lee KC. Site-Specific PEGylation for High-Yield Preparation of Lys21-Amine PEGylated Growth Hormone-Releasing Factor (GRF) (1-29) using a GRF(1-29) Derivative FMOC-Protected at Tyr1 and Lys12. Bioconjugate chemistry. 18(2):500-506 (2007)
Youn YS, Shin MJ, Chae SY, Jin CH, Kim TH, Lee KC. Biological and physicochemical evaluation of the conformational stability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Biotechnology Letters. 29(5):713-721 (2007)
Youn YS, Chae SY, Lee SK, Jeon JE, Shin HG, Lee KC. Evaluation of therapeutic potentials of site-specific PEGylated glucagon-like peptide-1 isomers as a type 2 anti-dibaetic treatment: Insulinotropic activity, glucose-stabilizing capability, and proteolytic stability. Biochemical Pharmacology. 73(1):84-93 (2007)
Lee S, Youn YS, Lee SH, Byun Y, Lee KC. PEGylated glucagon-like peptide-1 displays preserved effects on insulin release in isolated pancreatic islets and improved biological activity in db/db mice. Diabetologia. 49(7):1608-1611 (2006)
Lee SH, Lee S, Youn YS, Na DH, Chae SY, Byun Y, Lee KC. Synthesis, characterization and Pharmacokinetic Studies of PEGylated Glucagons-like Peptide-1. Bioconjugate Chemistry. 16(2):377-382 (2005)

Name Byung-Mu Lee
Position Division Professor
E-mail bmlee@skku.ac.kr
Office Tel 031)290-7708, 7748
Education 1975-1982 B.Sc., Sungkyunkwan University (Pharmacy)
1982-1984 M.P.H., Seoul National University (Environmental Health Sciences)
1984-1987 M.S.P.H., University of South Carolina (Toxicology)
1986-1989 Dr.P.H., Columbia University (Toxicology)
Work Experience 1986-1989 Columbia University (Research Assistant)
1989-1990 The Johns Hopkins University (post-doc)
1997 Department of Pharmacy, Sungkyunkwan University (Chair)
1990-present National Institute of Environmental Health Sciences (Visiting Professor) College of Pharmacy, Sungkyunkwan University (Professor)
Research Interests Mechanism of Carcinogensis
Investigation of Cancer Chemopreventive Agents
Cancer Risk Assessment and Biomarkers
Development of Health Foods and Antiaging Agents
Endocrine Disruptors
Selected Publications Lee BM, Koo HJ., Hershberger Assay for Antiandrogenic Effects of Phthalates., Journal of Toxicology and Environmental Health Part A. 70(15&16):1365-1370 (2007)
Lee BM, Shim GA. Dietary Exposure Estimation of Benzo[a]pyrene and Cancer Risk Assesment. Journal of Toxicology and Environmental Health Part A. 70(15&16):1391-1394 (2007)
Koo HJ, Lee BM. Human monitoring of phthalates and risk assessment. J. Toxicol. Environ Health A, 68:1379-1392 (2005)
Yoo EJ, Lee BM. Comparative Mutagenicity of Apicidin and Apicidin Derivatives (SD-0203 and SD-2007), Histone Deacetylase Inhibitors. J. Toxicol. Environ Health A. 68:2097-2109 (2005)
Kwack SJ, Lee BM. Correlation between DNA or protein adducts and benzo(a)pyrene diol epoxide I-triglyderide adduct detected in vitro and in vivo Carcinogenesis. Carcinogenesis. 21(4):629-32 (2000)

Name Seok-Yong Lee
Position Division Professor
E-mail sylee@skku.ac.kr
Office Tel 031)290-7715, 7758
Education 1982 B.Sc., Sungkyunkwan University (Pharmacy)
1984 M.Sc., Sungkyunkwan University (Pharmacology)
1989 Ph.D., Catholic University Medical College (Pharmacology)
Work Experience 1988-1997 Catholic University Medical College (Associate Professor)
1993-1995 University of Minnesota Medical School (Visiting Professor)
1997-2001 College of Pharmacy, Sungkyunkwan University (Associate Professor)
1999-present Graduate School of Clinical Pharmacy, Sungkyunkwan University (Chairman)
2002-2004 College of Pharmacy, Sungkyunkwan University (Chairman)
2002-present College of Pharmacy, Sungkyunkwan University (Professor)
Research Interests Neuropharmacology
Pharmacogenomics
Cardiovascular Pharmacology
Pharmacodynamics/Pharmacokinetics
Selected Publications Bae JW, Kim MJ, Park YS, Myung CS, Jang CG, Lee SY. Considerable interindividual variation in the pharmacokinetics of tolperisone HCI. International Journal of Clinical Pharmacology and Therapeutics. 45(2):110-113 (2007)
Lee SY, Kang JS, Song GY, Myung CS. Stress induces the expression of heterotrimeric G protein β subunits and the phosphorylation of PKB/Akt and ERK1/2 in rat brain. Neuroscience Research. 56(2):180-192 (2006)
Bae JW, Park YS, Sohn UD, Myung CS, Ryu BK, Jang CG, Lee SY. HPLC determination of tolperisone in human plasma. Archives of Pharmacal Research. 29(4):339-342 (2006)
Bae JW, Kim HK, Kim JH, Yang SI, Kim MJ, Jang CG, Park YS, Lee SY. Allele and genotype frequency of CYP2C9 in Korean population. British journal of clinical pharmacology. 60(4):418-22 (2005)
Yang SI, Park HY, Lee SH, Lee SJ, Han OY, Lim SC, Jang CG, Lee WS, Shin YH, Kim JJ, Lee SY. Transdermal eperisone elicits more potent and longer-lasting muscle relaxation than oral eperisone. PHARMACOLOGY.

Name Sun-Mee Lee
Position Division Professor
E-mail sunmee@skku.edu
Office Tel 031)290-7712, 7752
Education 1977-1981 B.Sc., Sungkyunkwan University (Pharmacy)
1981-1983 B.Sc., Sungkyunkwan University (Pharmacy)
1983-1986 Ph.D., Sungkyunkwan University (Pharmacology)
Work Experience 1989-1992 The Johns Hopkins University School of Medicine (Postdoctoral Fellow)
1992-1996 College of Pharmacy, Sungkyunkwan University (Assistant Professor)
1996-2001 College of Pharmacy, Sungkyunkwan University (Associate Professor)
2002-2002 University of North Carolina (Visiting Professor)
2001-present College of Pharmacy, Sungkyunkwan University (Professor)
Research Interests Development of Hepatoprotective Drugs
Antioxidants and Free Radicals
Organ Oxidative Stress Injury
Pharmacological Interventions for Sepsis
Selected Publications Eum HA, Cha YN, Lee SM. Necrosis and apoptosis: sequence of liver damage following reperfusion after 60 min ischemia in rats. Biochemical and Biophysical Research Communications. 358(2):500-505 (2007)
Lee WY, Lee SM,. Synergistic protective effect of ischemic preconditioning and allopurinol on ischemia
reperfusion injury in rat liver. Biochemical and Biophysical Research Communications. 349(3):1087-1093 (2006)
Lee WY, Lee SM. Ischemic Preconditioning Protects Post-ischemic Oxidative Damage to Mitochondria in Rat Liver.
Shock. 24(4):370-375 (2005)
Lee SM, Clemens MG. Glucagon increases gap junctional intercellular communication via cAMP in the isolated perfused rat liver. Shock. 22(1):82-7 (2004)
Eum HA, Lee SM. Effects of Trolox on the activity and gene expression of cytochrome P450 in hepatic ischemia/reperfusion. BRITISH JOURNAL OF PHARMACOLOGY. 142(1):35-42 (2004)

Name Choon-Gon Jang
Position Division Professor
E-mail jang@skku.edu
Office Tel 031)290-7780, 7770
Education 1987 B.Sc., Chungbuk National University (Pharmacy)
1989 M.Sc., Chungbuk National University (Pharmacology)
1995 Ph.D., Chungbuk National University (Pharmacology)
Work Experience 1992-1992 Faculty of Pharmaceutical Sciences, Nagasaki University, Japan
1995-1996 Korea Research Institute of Chemical Technology (Post-doctoral Fellow)
1996-1999 University of Mississippi Medical Center, U.S.A (Research Associate)
2000-2001 School of Medicine, Hallym University ( Research assistant professor)
2001-present College of Pharmacy, Sungkyunkwan University ( Associate professor)
Research Interests Neuropharmacology
Neurochemical study for rewarding effects of drugs of abuse
Drug development for CNS disease (depression, anxiety, memory deficit) from natural products
Selected Publications Yu HS, Lee SY, Jang CG., Involvement of 5-HT1A and GABAA receptors in anxiolytic-like effects of Cinnamomum cassia in mice. Pharmacol Biochem Behav. 87(1):164-70 (2007)
Kim JH, Kim SY, Lee SY, Jang CG., Antidepressant-like effects of Albizzia julibrissin in mice: involvement of the 5-HT1A receptor system. Pharmacol Biochem Behav. 87(1):41-47 (2007)
Yoo JH, Cho JH, Yu HS, Lee KW, Lee BH, Jeong SM, Nah SY, Kim HC, Lee SY, Jang CG., Involvement of 5-HT3 receptor in the development and expression of methamphetamine-induced behavioral sensitization: 5-HT3A receptor channel and binding study. Journal of Neurochemistry. 99(3):976-988 (2006)
Yoo JH, Yang EM, Cho JH, Lee JH, Jeong SM, Nah SY, Kim HC, Kim KW, Kim SH, Lee SY, Jang CG., Inhibitory effects of berberine against morphine-induced locomotor sensitization and analgesic tolerance in mice. Neuroscience. 142(4):953-61. (2006)
Yoo JH, Cho JH, Lee SY, Lee S, Loh HH, Ho IK, Jang CG., Differential effects of morphine- and cocaine-induced nNOS immunoreactivity in the dentate gyrus of hippocampus of mice lacking mu-opioid receptors. Neuroscience Letters. 395(2):98-102 (2006)

Name Kyu-Hyuck Chung
Position Division Professor
E-mail Khchung@skku.edu
Office Tel 031)290-7714, 7754
Education 1977-1981 B.Sc., Sungkyunkwan University (Pharmacy)
1981-1983 M.Sc., Sungkyunkwan Universtiy (Biopharmacy)
1986-1989 Ph.D., Sungkyunkwan Universtiy (Environmental Toxicology)
Work Experience 1990-1994 National Institute of Scientific Investigation, Korea (Senior Researcher)
1992-1995 Louisiana State University (Visiting Fellow)
1995-1999 College of Pharmacy, Sungkyunkwan University (Assistant Professor)
1999-2004 College of Pharmacy, Sungkyunkwan University (Associate Professor)
2004-Present College of Pharmacy, Sungkyunkwan University (Professor)
Research Interests Receptor-mediated toxicity of environmental endocrine disruptors
Biological systems for environmental biomonitoring and toxicolgy
Effect-directed identification of toxicants in complex environmental samples
Selected Publications Oh SM, Chung KH. Identification of mammalian cell genotoxins in respirable diesel exhaust particles by bioassay directed chemical analysis. Toxicology Letters. 161(3):226-235 (2006)
Lee SY, Oh SM, Chung KH. Estrogenic effects of marijuana smoke condensate and cannabinoid compounds. Toxicology and Applied Pharmacology. 214(3):270-278 (2006)
Oh SM, Chung KH. Antiestrogenic activities of Ginkgo biloba extracts. Journal of Steroid Biochemistry and Molecular Biology. 100(4-5):167-176 (2006)
Oh SM, Park K, Chung KH. Combination of in vitro bioassays encompassing different mechanisms to determine the endocrine disrupting effects of river water. Science of the Total Environment. 354(2-3):252-264 (2006)
Kwon YI, Yeon JD, Oh SM, Chung KH. Protective effects of ursodeoxycholic acid against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced testicular damage in mice. 194:239-247 (2004)

Name Young-Hoon Jung,
Position Division Professor
E-mail yhjung@skku.ac.kr
Office Tel 031)290-7711, 7751
Education 1977-1981 B.Sc., Seoul National University (Pharmacy)
1981-1983 M.Sc., Seoul National University (Manufacturing Pharmacy)
1985-1989 Ph.D., University of California, Los Angeles (Organic Chemistry)
Work Experience 1989-1990 Harvard University (Post-doctoral Fellow)
1990-1994 Dongduck Women's University (Assistant Professor)
1994-1999 Sungkyunkwan University (Associate Professor)
1999-Present Sungkyunkwan University (Professor)
2001-2002 University of California, Los Angeles (Visiting Professor)
Research Interests Development of novel antitumor agents from natural products
Synthesis of optically active amino acids( -OH, NH2-amino acids, etc.)
Development of novel organic reactions
Development of efficient synthetic routes
Selected Publications Kim IS, Li QR, Lee JK, Lee SH, Lim JK, Zee OP, Jung YH. An Efficient Synthesis of Aminocyclopentitols via the Stereoselective Amination of Polybenzyl Ethers Using Chlorosulfonyl Isocyanate. Synlett. 11:1711-1714 (2007)
Kim IS, Dong GR, Jung YH. Palladium(Ⅱ)-Catalyzed Isomerization of Olefins with Tributyltin Hydride. Journal of Organic Chemistry. 72(14):5424-5426 (2007)
In Su Kim, Chae Baek Ryu, Qing Ri Li, Ok Pyo Zee and Young Hoon Jung. An efficient stereoselective synthesis of (+)-deoxoprosophylline. Tetrahedron Letters. 48:6258-6261 (2007)
Kim IS, Zee OP, Jung YH. Regioselective and Diastereoselective Amination of Polybenzyl Ethers Using Chlorosulfonyl Isocyanate: Total Syntheses of 1,4-Dideoxy-1,4-imino-D-arabinitol and (-)-Lentiginosine. Organic Letters. 8(18):4101-4104 (2006)
Kim JD, Kim IS, Jin CH, Zee OP, Jung YH. Regioselective and diastereoselective amination with use of chlorosulfonyl isocyanate: A short and efficient synthesis of (-)-Cytoxazone. Org. Lett. 7(18):4025-4028 (2005)

Name Dong-Gyu Jo
Position Division Professor
E-mail jodg@skku.edu
Office Tel 031)290-7782, 7776
Education 1996 B.Sc., Kyung Hee University (Biology)
1998 M.Sc., Gwangju Institute of Science and Technology (Biochemistry)
2002 Ph.D., Gwangju Institute of Science and Technology (Molecular Neurobiology)
Work Experience 2002-2003 Life Phenomena and Function Research Institute, GIST, Korea (Postdoctoral fellow)
2003-2007 National Institute on Aging/National Institutes of Health, USA (Postdoctoral fellow)
2007-present College of Pharmacy, Sungkyunkwan University (Assistant professor)
Research Interests Molecular mechanism of brain aging, neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, ischemic stroke) and diabetes
Neuronal vulnerability and neuronal cell death of diseases
Identification of therapeutic targets of these diseases
Development of new screening strategy and screening to discover new candidates of drugs
Selected Publications Hyun DH, Emerson SS, Jo DG, Mattson MP & de Cabo R. Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. Proc. Natl. Acad. Sci. U. S. A. 103(52):19908-19912 (2007)
Jo DG, Arumugam T, Chan S, Yilmaz G, Tang SC, Cheng A, Gleichmann M, Okun E, Dixit VD, Chigurupati S, Mughal MR, Ouyang X, Miele L, Magnus T, Poosala S, Granger DN, & Mattson MP. Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nature Medicine. 12(6):621-623 (2006)
Mattson MP, Cutler RG & Jo DG. Alzheimer peptides perturb lipid-regulating enzymes. Nature Cell Biology. 7(11):1045-1047 (2005)
Jo DG, Jun J, Chang J, Hong Y, Song S, Cho D, Shim S, Lee H, Cho C, Kim D & Jung YK. Calcium Binding ARC Mediates Regulation of Caspase-8 and Cell Death. Mol. Cell. Biol. 24(22):9763-9770 (2004)
Jo DG, Kim M, Choi Y, Kim I, Song Y, Woo H, Chung C & Jung YK. Pro-apoptotic function of calsenilin/DREAM/KChIP3. FASEB J. 15(3):589-591 (2001)

Name Eun-Jung Cho
Position Division Associate Professor
E-mail echo@skku.edu
Office Tel 031)290-7781, 7766
Education 1989 B.S. Department of Microbiology, Seoul National University
1990 M.S., Seoul National University (Molecular Biology)
1996 Ph.D., Seoul National University (Molecular Biology)
Work Experience 1996-2001 Harvard Medical School, USA (Postdoctoral fellow)
2001-2005 College of Pharmacy, Sungkyunkwan University (Assistant Professor)
2005-present College of Pharmacy, Sungkyunkwan University (Associate Professor)
2007-present Pharmaceutical Society of Korea (Associate Editor, Archives of Pharmacal Research)
Research Interests Regulation of eukaryotic gene expression
Chromatin dynamics during cell differentiation and cancer development
Genome maintenance and transcription memory
Selected Publications Roe JS, Kim HS, Lee SM, Kim ST, Cho EJ, Youn HD. p53 Stabilization and Transactivation by a von Hippel-Lindau Protein. Molecular Cell. 22(4):395-405 (2006)
Kim SY, Kang JK, Kim YK, Seo DW, Ahn SH, Lee JC, Lee CH, You JS, Cho EJ, Lee HW, Han JW. Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites. Biochemical and Biophysical Research Communications. 342(4):1168-1173 (2006)
Seol JH, Kim HJ, Yang YJ, Kim ST, Youn HD, Han JW, Lee HW, Cho EJ. Different roles of histone H3 lysine 4 methylation in chromatin maintenance.Biochemical and Biophysical Research Communications. 349(2):463-470 (2006)
Kim H, Lee JE, Kim BY, Cho EJ, Kim ST, Youn HD. Menin represses JunD transcriptional activity in protein kinase C theta-mediated Nur77 expression. Experimental & molecular medicine. 37(5):466-475 (2005)
Kim HJ, Jeong SH, Heo JH, Jeong SJ, Kim ST, Youn HD, Han JW, Lee HW, Cho EJ. mRNA capping enzyme activity is coupled to an early transcription elongation. MOLECULAR AND CELLULAR BIOLOGY. 24(14):6184-6193 (2004)

Name OkPyo Zee
Position Division Professor
E-mail opzee@skku.ac.kr
Office Tel 031)290-7705, 7745
Education 1971 B.Sc., College of Pharmacy, Sungkyunkwan University (Pharmacy)
1973 M.Sc., College of Pharmacy, Sungkyunkwan University (Pharmaceutical Biology)
1981 Dr.rer.nat.,Ludwig-Maximillian Universitaet der Muenchen (Pharmaceutical Biology)
Work Experience 1971-1977 Dong-A Pharmaceutical Company (Dong-A Pharmaceutical Company)
1977-1982 Institute of Pharmaceutical Biology, University of Muenchen (Research Associate)
1982-1993 Natural Product Research Laboratory, Korea Research Institute for Chemical Technology (Head)
1993-2002 College of Pharmacy, Sungkyunkwan University (Dean and Professor)
2000-2002 The Korean Pharmaceutical College Association (President)
2002-Present Korea Pharmacist Association (Vice President) Korea President Committee of Pharmacy Development (Vice Chairman)
Research Interests Biologically active ingredients of herbal medicine
Anticancer agents
Immunoregulators
Selected Publications Hong J, Yokomakura A, Nakano Y, Ishihara K, Kaneda M, Onodera M, Nakahama K, Morita I, Niikura K, Ahn JW, Zee O, Ohuchi K. Inhibition of vacular-type (H+)-ATPase by the cytostatic macrolide apicularen A and its role in apicularen A-induced apoptosis in RAW 264.7 cells. FEBS Letters. 580(11):2723-2730 (2006)
Kang SC, Lee CM, Choi H, Lee JH, Oh JS, Kwak JH, Zee OP. Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities. Phytotherapy research. 20(11):1017-1019 (2006)
Hong J, Ishihara K, Zee O, Ohuchi K. Induction of apoptosis by apicularen A in human promyelocytic leukemia cell line HL-60. Planta Medica. 71(4):306-312 (2005)
Hong JJ, Yokomakura Aya, Nakano Yasuhiro, Ban HS, Lshihara Kenji, Ahn JW, Zee OP, Ohuchi Kazuo. Induction of nitric oxide production by the cytostatic macrolide apicularen A [2.4-heptadienamide, N-[(1E)-3-[3S, 5R,7R,9S)-3,4,5,6,7,8,9,10-octahydro-7, 14dihydroxy-1-oxo-5,9-epoxy-1H-2-benzoxacyclododecin-3-yl]-1 propenyl]-,(2Z,4Z)-(9C1)] and possible role of nitric oxide in apicularen A-induced. 312(3):968-977 (2005)
Kenji Ishiharam Hong JJ, Zee OP, Kazuo Ohuchi. Possible mechanism of action of the histone deacetylase inhibitors for the induction of differentiation of HL-60 clone 15 cell into eosinophils. British Journal of Pharmacology. 142:1020-1030 (2004)

Name Suhkneung Pyo
Position Division Professor
E-mail snpyo@skku.ac.kr
Office Tel 031)290-7713, 7753
Education 1980 B.Sc., Sungkyunkwan University (Pharmacy)
1982 M.Sc., Sungkyunkwan University (Pharmacy)
1987 M.Sc., Texas Tech University Health Science Center (Virology)
1991 Ph.D., University of South Carolina, School of Medicine (Immunology)
Work Experience 1991-1993 New York University (Research Associate)
1993-1997 College of Pharmacy, Sungkyunkwan University (Assistant Professor)
1996-1998 College of Pharmacy, Sungkyunkwan University (Chairman)
1997-2002 College of Pharmacy, Sungkyunkwan University (Associate Professor)
2000-2001 Friedrich Miescher Institute - Swiss (Visiting Scientist)
2002-present College of Pharmacy, Sungkyunkwan University (Professor)
2003-2006 BK21 Research program for development of new drug by the regulation of drug receptor (Program Director)
Research Interests Molecular mechanism of Immune cell apoptosis by stress
Regulation of macrophage gene expression by transcription factor Ikaros
Development of immunomodulators for chronic diseases
Development of vaccine and immunodiagnostic kit
Selected Publications Yang MR, Lee SR, Oh W, Lee EW, Yeh JY, Nah JJ, Joo YS, Shin J, Lee HW, Pyo S, Song J. West Nile Virus Capsid protein induces p53-mediated apoptosis via the sequestration of HDM2 to the nucleolus. Cellular microbiology. (2007)
Lee SR, Kwak JH, Kim HJ, Pyo S. Neuroprotective effects of kobophenol A against the withdrawal of tropic support, nitrosative stress, and mitochondrial damage in SH-SY5Y neuroblastoma cells. Bioorganic & medicinal chemistry letters. 17(7):1879-1882 (2007)
Oh W, Yang MR, Lee EW, Park KM, Pyo S, Yang JS, Lee HW, Song J. Jab1 mediates cytoplasmic localization and degradation of west nile virus capsid protein. Journal of biological chemistry. Journal of biological chemistry. 281(40):30166-30174 (2006)
Son EW, Mo SJ, Rhee DK, Pyo S. Inhibition of ICAM-1 expression by garlic component, allicin, in gamma-irradiated human vascular endothelial cells via downregulation of the JNK signaling pathway. International Immunopharmacology. 6(12):1788-1795 (2006)
Park SY, Cho SJ, Kwon HC, Lee KR, Rhee DK, Pyo S. Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA. Cancer Lett. 224(1):123-32 (2005)

Name Jeung Whan Han
Position Division Professor
E-mail jhhan551@skku.edu
Office Tel 031)290-7716, 7742
Education 1982 B.Sc., Sungkyunkwan University (Pharmacy)
1984 M.Sc., Sungkyunkwan University (Biopharmacy)
1991 Ph.D., Bochum University, Germany (Biochemistry)
Work Experience 1991-1992 Bochum University, Germany (Post-doctoral Fellow)
1992-1995 Friedrich Miescher Institute, Switzerland (Post-doctoral Fellow)
1996-2000 College of Pharmacy, Sungkyunkwan University (Assistant Professor)
2001-2005 College of Pharmacy, Sungkyunkwan University (Assistant Professor)
2006-Present College of Pharmacy, Sungkyunkwan University (Professor)
Research Interests Regulation of RNA Metabolism by Histone Covalent Modification.
Reprogramming of somatic cells using methods of epigenetic modifications upon cloning of pigs by nuclear transfer.
Studies on pathogenetic mechanism of neurodegenerative and psychiatric diseases and development of tools for preventing and treating these disease.
Role of protein L-isoaspartyl O-methyltransferase in regulation of transcriptional activity of p53
Selected Publications Chun JK, Seo DW, Ahn SH, Park JH, You JS, Lee CH, Lee JC, Kim YK, Han JW. Suppression of the NF-κB Signaling Pathway by Ergolide, Sesquiterpene Lactone, in HeLa cells. Journal of Pharmacy and Pharmacology. 59(4):561-566 (2007)
Eun DW, Ahn SH, You JS, Park JW, Lee EK, Lee HN, Kang GM, Lee JC, Choi WS, Seo DW, Han JW. PKCε Is Essential for Gelsolin Expression by Histone Deacetylase Inhibitor Apicidin in Human Cervix Cancer Cells. Biochemical and Biophysical Research Communications. 354(3):769-775 (2007)
Kim S, Kang JK, Kim YK, Seo DW, Ahn SH, Lee JC, Lee CH, You JS, Cho EJ, Lee HW, Han JW. Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites. Biochemical and Biophysical Research Communications. 342(4):1168-1173 (2006)
Kang JK, Park KW, Chung YG, You JS, Kim YK, Lee SH, Hong SP, Choi KM, Heo KN, Seol JG, Lee JH, Jin DI, Park CS, Seo JS, Lee HW, Han JW. Coordinated Change of a Ratio of Methylated H3-lysine 4 or Acetylated H3 to Acetylated H4 and DNA Methylation Is Associated with Tissue-Specific Gene Expression in Cloned Pig. Experimental & Molecular Medicine. 39(1):84-96 (2007)
Kim YK, Lee EK, Kang JK, Kim JA, You JS, Park JH, Seo DW, Hwang JW, Kim SN, Lee HY, Lee HW, Han JW. Activation of NF-kB by HDAC inhibitor apicidin through Sp-1dependent de novo protein synthesis: its implication for resistance to apoptosis. Cell Death and Differentiation. 13(12):2033-2041 (2006)

Name Won-Hun Ham
Position Division Professor
E-mail whham@skku.edu
Office Tel 031)290-7706, 7746
Education 1971-1975 B.Sc., Seoul National University (Pharmacy)
1977-1979 M.Sc., Seoul National University (Pharmacy)
1981-1986 Ph.D., Ohio State University (Organic Chemistry)
Work Experience 1986-1987 Depertment of Chemistry, Harvard University (Post-doctoral Fellow)
1987-1990 Korea Institute of Science and Technology - KIST (Principal Researcher)
1990-1999 College of Pharmacy, Sungkyunkwan University (Associate Professor)
1999-Present College of Pharmacy, Sungkyunkwan University (Professor)
2002-Present College of Pharmacy, Sungkyunkwan Universit (Dean)
Research Interests Total synthesis of biologically active natural products
Development of new synthetic methodology for chiral building blocks
Synthetic process development for commercial drugs
New drug research
Selected Publications Joo JE, Lee KY, Pharm VT, Ham WH. Stereoselective Ingramolecular Oxazine Formation via π-Allylpalladium Complex Catalyzed by Pd0. European Journal of Organic Chemistry. 2007(10):1586-1593 (2007)

Joo JE, Tian YS, Pharm VT, Oh CY, Ham WH. Stereoselective Synthesis of (+)-Polyoxamic Acid based on the Synthesis of Chiral Oxazine. Tetrahedron Letters. (2007)

Pyun SJ, Lee KY, Oh CY, Joo JE, Cheon SH, Ham WH. Total synthesis of 1-deoxygulonojirimycin. Revision of theabsolute configuration of the natural product. Tetrahedron. 61(6):1413-1416 (2005)

Yoon YJ, Joo JE, Lee KY, Kim YH, Oh CY, Ham WH. Asymmetric synthesis of (+)-L-733,060. Tetrahedron Letters. 46(5):739-741 (2005)

Shin HI, Rim JG, Lee KS, Kim YS, Nam DH, Shin HI, Chang JH, Oh CY, Ham WH. Synthesis of carbon-14 labelled gemifloxacin. Journal of labelled compounds and radiopharmaceuticals. 47:779-786 (2004)